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Barkmeier and colleagues compared the effect of multiple antihyperglycemic agentsnamely SGLT-2I, dipeptidyl peptidase-4 (DPP-4), GLP-1RA, and sulfonylureason the need for treatment of diabetic macular edema or PDR in a cohort of 371,698 patients using US claims data

The underlying cause may stem from the profound ways these drugs alter systemic energy balance, appetite signals, and central nervous system pathways

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Thyroid tumours (in animals): In rats, these drugs caused rare thyroid tumours

Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation