why does glp 1 make you nauseous The nausea that can come with a GLP-1 isn't random bad luck, and it isn't a sign the medication is wrong for you. It's a predictable effect of exactly what the medication is doing., These medications GLP-1RA Essentials in Gastroenterology: Side

Initial studies found that PYY increased POMC mRNA and induced electrophysiological activation of these neurons

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While on the reduced dose frequency, patients on average experienced a slight additional loss of weight

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Numbers in parentheses represent the standard deviation

At the end of the 28-day period, study subjects experienced significant weight loss (2.3 kg vs 0.5 kg) compared to saline treated controls in addition to concurrent changes in leptin and adiponectin suggesting reduction in adiposity (32)