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It amplifies gastrointestinal side effects without a proven increase in benefit, and no clinical trial has studied the combination

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The TECOS trial showed no difference between the placebo and a sitagliptin group (Table 2) [47,48,49]

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We find that ROS production correlates to a binding mode where two imidazole nitrogen atoms coordinate to the copper-ion leaving the remaining binding sites free for interaction with e.g