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Previous efforts using cerium oxide nanoparticles and other inorganic platforms demonstrated commendable antioxidant capabilities but often lacked robust targeting mechanisms or detailed mechanistic insight ( While these findings are promising, several considerations merit further inquiry

Each dose level in the titration protocol typically lasts 4 weeks before increasing

Pills/troches = needle-free and convenient, but exposure can be lower or more variable person-to-person and product-to-product

Both require collagen synthesis, extracellular matrix formation, and tissue remodeling

Starting with a lower dose and gradually increasing it is a common approach to minimize discomfort

Brotto LA, Basson R