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DiNicolantonio 2013 Mayo Clinic Proceedings 13 RCT3,629 AMI L-carnitine 27%OR 0.73, 95% CI 0.54-0.99 65% 40% [1] 2

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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

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