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[2] [15] Nitrous oxide misuse is an increasingly recognised cause of functional B12 deficiency and should be considered in relevant cases

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They found most of these events occurred within the first 4 months of therapy, and skin was the commonly involved site, followed by the gastrointestinal and the endocrine system

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Infected nails gradually soften and become easier to trim as the fungus dies off, with thickness returning to normal levels over 6-12 months of consistent treatment