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1 Despite these constraints, the commercial consequence has been significant: Medicare logged $27.5 billion in gross GLP-1 spending across 21.8 million claims in 2024, entirely under FDA-approved indications other than obesity

LY3437943 is a single-peptide triple GCGR/GIPR/GLP-1R agonist characterized in vitro and in vivo (A) Structure schematic of the single-molecule, triple agonist LY3437943 (LY) engaging the GCGR, GIPR, GLP-1R

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annual revenues, each additional year of exclusivity was worth approximately $6 billion [4]