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However, these modest lipid changes were insufficient to explain the beneficial cardiovascular effects of etanercept [374]

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It then asks why well-powered trials have largely failed where smaller studies and real-world data succeeded, with attention to brain exposure, trial design, and patient selection, and outlines what the next generation of studies will need to test the hypothesis properly

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Various systems are available for identifying subjects with generalized JHM, and the Beighton score is the most widely accepted one (Table 7) [10]

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