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Notably, magnitudes of weight loss exceeding 10% can lead to remission of T2DM [26-29]

Second, kidney injury in diabetes appears to be related to glomerular hyperfiltration [93, 94], which is likely related to an excessive reabsorption of sodium in the proximal tubule, leading diminished delivery of sodium to the macula densa, and (via tubuloglomerular feedback) to afferent arteriolar dilatation [95, 96]

However, if symptoms are severe or do not improve despite dietary modifications and smaller meals after two weeks, the drug should be stopped

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LR3 IGF-1 infusion in animal models stimulates organ growth (adrenals, gut, kidneys, spleen) while suppressing endogenous IGF-1 and IGFBP levels (Bastian et al., 1993)