Obesity Coverage: A Divided Perspective Obesity affects over 40% of adults in the United States and has been recognized as a chronic disease by the American Medical Association since 2013
T2D patients with severe renal impairment are not eligible for SGLT2 inhibitors, and GLP-1RAs could be an important therapeutic option for these patients
Semaglutide GLP-1 affects the hypothalamus region of the brain, slowing down how fast the stomach empties and delaying gastric emptying into the intestine
Several mid-stage trials will read out in 2025 to provide important proof points for novel MoAs and their potential for differentiation, e.g., Lillys bimagrumab (activin/myostatin type II receptor inhibitor) in combination with semaglutide, aiming to deliver weight loss while preserving muscle mass (phase 2b)
In a promising advance for diabetes care, researchers at National Taiwan University (NTU) are exploring the potential of GLP-1 receptor agonists (GLP-1 RAs) to slow the progression of kidney disease and reduce mortality among diabetic patients with acute kidney conditions
Madsbad S, Dirksen C, Holst JJ