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Meanwhile, we treated HepG2 cells with different concentrations of hDPP4 and found that the levels of IKK, p-P65 S536 /P65 ratio, and p-IKB S36 /IKB ratio were significantly enhanced to different degrees, but the activation of IKK-NFB signaling pathway induced by hDPP4 was remarkably inactivated by sitagliptin (Fig

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Though peptide-based drugs are a natural choice for treating hormonal conditions, experts say small molecules offer several advantages, including easy absorption by gut cells, since they are vastly smaller than peptides