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In some patients, particularly high doses of B12 can trigger a breakout of acne

Cyanocobalamin must first be converted into active forms of B12 in the body

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Vegetarians & Vegans Older adults People with pernicious anemia or GI absorption disorders (like Crohn's or celiac disease) Individuals after certain surgeries (such as gastric bypass) Pregnant women People on chronic metformin or proton pump inhibitors (PPIs) How much does a B12 shot typically cost

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The timeline for initial weight loss varies between individuals, and the same applies to tirzepatide