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81 These discoveries have enabled ASOs to be applied in disease treatment via more diverse mechanisms

it undergoes partial first-pass metabolism in the gut and liver, where it may be hydrolyzed by glutaminases, with ~5070% escaping to systemic circulation depending on dose [56]

10.1007/s00228-009-0735-3 [DOI] [PubMed] [Google Scholar] 258.Henriksen K, Andersen JR, Riis BJ, Mehta N, Tavakkol R, Alexandersen P, et al

Chronic treatment should be with an oral B 12preparation

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