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doi: 10.3402/ecrj.v2.26385

Earlier Predictive Value: During early acute liver injury, GR activity rises significantly, with its peak appearing earlier than that of transaminases (ALT, AST), providing a more timely window for clinical intervention [4] Major liver disease guidelines from the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) emphasize the need to detect early hepatocyte stress and dysfunction, particularly in conditions like drug-induced liver injury [5,6]

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Indeed, in vitro and epidemiological studies have demonstrated elevating effects of glutamine on GLP-1 secretion in GLUTage cells more than other amino acids and even glucose [15, 41]

studies on extracellular matrix dynamics and peptide-mediated structural signaling These studies continue to support growing research interest in peptide-copper complexes associated with connective signaling behavior and adaptive structural communication