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At position 3 on the chain Glu(E) was substituted with Arg(R), which gives the name LR3

The accumulation of A leads to the overactivation of microglia and astrocytes, triggering release of pro-inflammatory cytokines, such as IL-1 and TNF-, that sustain chronic neuroinflammation [249]

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The lipid profile of TMX-exposed rats indicated a substantial increase in serum TC and TG, probably due to lipoprotein lipase hypoactivity, which breaks down triglycerides