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Jia J-S, Ge N, Wang Q-Y, Zhao L-T, Chen C, Chen J-W

Consistent with Kidney Disease: Improving Global Outcomes (KDIGO) 2017and reaffirmed by the 2024 KDIGO Controversies Conferencecare should prioritize personalized management along bone (osteoporosis/fracture) and cardiovascular (calcification/left ventricular hypertrophy, LVH) axes: replete deficiency with nutritional vitamin D (D3 preferred

Pre-supplementation testing of TPO antibodies, TSH, free T4, and glutathione-dependent enzyme activity (GPx, GR) informs realistic expectations and treatment personalization

Only one (somatropin) holds a UK marketing authorisation

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Daily consistency for at least 48 weeks matters more than chasing one "perfect" dosing hour.