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While challenges with adherence, side effects, and weight regain upon discontinuation have prompted the search for additional strategies, targets like GLP-1R, GIPR, and GDF8 (Myostatin) still remain the most highly relevant and active areas of research for developing effective obesity treatments

It has been shown that ceramide is incorporated to stabilise lipid rafts (LR), which are regions of cell membranes with a distinct lipid composition and which appear to act as platforms, called ceramide-enriched membrane platforms [13,14], to localize proteins involved in intracellular signalling

J Food Compos Anal 21:589598

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, & Jin, C

Furthermore, Keap1, a cysteine rich protein which binds to NRF2 and regulates oxidative and electrophilic stress, was co-localized with intracellular misfolded protein inclusions in motor neurons in the spinal cord of ALS patients