extremely unstable metabolites may bind covalently to and inactivate the enzyme that forms them, whereas more stable species may be able to diffuse to a distant site, for example DNA, and initiate changes such as cancer
This includes cancer, heart disease, diabetes, and depression
4B), while blocking STAT3 by AG490 inhibited STAT3, but not JAK1 or JAK2 (Fig
In cultured fibroblasts, exposure to the compound at concentrations as low as 10 nM has produced measurable increases in collagen synthesis within 48 hours
References Dennis A, Wamil M, Alberts J, Oben J, Cuthbertson DJ, Wootton D, et al
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