They found that in addition to slowing the progression of degeneration in the treatment group compared to controls, the peptide also improved levels of the protein aggrecan
The ones we notice are usually not because they are a good result
MNA cells rely on an elevated antioxidant response through the Xc-/glutathione (GSH) pathway to scavenge lipid hydroperoxides, a by-product formed from excess H 2 O 2 ( We recently discovered in a drug screen that Diphenyleneiodonium chloride (DPI) selectively induces cell death of MNA NB cells in vitro and decreases tumor growth in vivo ( Although precision therapy for individual patients remains limited, combination therapy has the potential to enhance treatment efficacy while potentially reducing reliance on highly toxic chemotherapy ( 2 Results 2.1 MitoQ induces cell death and differentiation in neuroblastoma cells and potentiates DPI-induced cytotoxicity To investigate whether enhanced ROS production mediates the cytotoxic effects of DPI, we used MitoQ, a ROS scavenger that selectively accumulates in mitochondria ( Supplementary Figure S1 )

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Annals of the New York Academy of Sciences, 1112(1), 112