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Medicine 98 , e15090 (2019)

Oxidative stress is a major contributor to the high mortality rates associated with SARS-CoV-2 infections (Poljsak et al., 2013

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J., Qiu, Y., Kido, T

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When cells respond to oxidative stress, large amounts of highly reactive and toxic ROS are produced and lead to adverse changes in cellular components such as proteins, lipids, and DNA damage [41].Cell membrane is particularly vulnerable to ROS damage due to its high polyunsaturated fatty acids (PUFA), called lipid peroxidation, which is the most significant feature of ferroptosis