In PsA, the phase 3b TOGETHER-PsA trial (NCT06588296) assesses the combined use of ixekizumab and tirzepatide in patients with active disease and concomitant overweight or obesity, while the phase 4 TOGETHER AMPLIFY-PsA study (NCT06864026) examines the effectiveness of adding tirzepatide to ixekizumab in clinical practice over 12 months
Triglyceride improvement correlates with weight loss and improved insulin sensitivity, while LDL response depends on baseline status and genetic lipid factors
A diet high in carbohydrates increases circulating levels of insulin, which promotes fat storage, increased hunger, and cravings
These data are promising, but they should not be oversold
If you are ready to make these changes, consider finding a team who offers personalized, long-term support
A new entrant was about to change the landscape again: semaglutide , a molecule even more potent at weight reduction and glycemic control, which would further elevate the GLP-1 class including heading into oral dosage forms and unprecedented trial results