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Statistical tests are based on two-sided Wald tests using Kenward-Roger degrees of freedom when comparing pairs of estimated marginal means extracted from the linear mixed model

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As per the results obtained, clearance for the hydroxychalcone was found to be 0.0417 ml/h/kg which is the least, followed by diosgenin (0.22 ml/h/kg) and charantin (0.11 ml/h/kg), indicating higher AUC for hydroxychalcone and the highest residence time of the drug in the systematic circulation and that slower will be the decline in plasma concentration of hydroxychalcone

doi: 10.1128/MCB.01204-10

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