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Additionally, SIRT2 increases the deacetylation level of c-Jun/c-Fos and increases the binding activity of AP-1 and the inflammatory factor MCP-1, thereby aggravating the HG/PA-induced inflammatory response (Chen et al., 2025)

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It also improves mitochondrial health, which supplies the energy needed for efficient tissue regeneration

Research has reported that blocking NNMT was associated with increased energy expenditure and reduced fat mass in animal studies, independent of diet or exercise changes

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