The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE(-/-) mice by blocking monocyte/macrophage activation
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For instance, the RaTG13 S protein binds hACE2 with relatively low efficiency and does not exhibit significant infectivity 47
Thus, initial treatment with GLP-1 RAs can result in negative effects on body composition with profound loss of muscle while treatment interruptions and treatment cycling can further exacerbate this problem 14,15,16
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