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Studies in aged rats show that mitochondrial membrane potential, cardiolipin content, respiratory control ratio, and cellular oxygen uptake are significantly reduced compared to young animals, while oxidative stress markers are elevated

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It was found that the binding of all the phytochemicals induce a higher fluctuation in the distant regions from the active site, especially in the region post 400 residue number (Fig

Apart from this hydrophobic region, it seems that GLP-1R prefers a carboxyl group at the end of the side chain while GIPR can accommodate, but does not favor, an alkaline group