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Those taking antihypertensive medications require medical supervision before supplementation [33]

Many of the current drug formulations available require injection, negatively influencing patients compliance to therapy, and present important side effects due to the ubiquitous distribution of the targeting receptors

Cell Mol Life Sci 76(10):19671985

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The GLP-1R agonist had beneficial effects on systolic and diastolic blood pressure, plasma concentrations of cholesterol, and glycemic control, but did not have a significant impact on plasma concentrations of liver enzymes

Farina M, Brando R, Lara FS, Soares FA, Souza DO, Rocha JB (2003) Mechanisms of the inhibitory effects of selenium and mercury on the activity of delta-aminolevulinate dehydratase from mouse liver, kidney and brain