[,] GLP-1 receptor agonists are currently classified as Food and Drug Administration (FDA) pregnancy category C, indicating that while animal studies have shown adverse fetal effects, adequate and well-controlled studies in pregnant women are deficient, and these agents are not recommended for use during pregnancy
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In adults with obesity, along with diet and exercise, Nausea was generally transient 4 Most occurrences of nausea did not lead to permanent discontinuation of Wegovy HD STEP UP: Reported nausea (median duration 6 days) In STEP UP, nausea was reported in all treatment arms and was most prevalent during the dose-escalation period 4 Nausea was not prospectively measured at each patient visit in clinical trials
Still, as more entrants bring new GLP-1 or multi-agonist drugs to market, the competitive pressure is likely to increase potentially improving affordability and access for a broader patient population
Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats
Upregulation of -ENaC induces pancreatic -cell dysfunction, ER stress, and SIRT2 degradation
