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Quick Answer: GLP-1 receptor agonists primarily influence hormones indirectly through weight loss and improved insulin sensitivity rather than direct hormonal modulation
Severe fluid loss can lead to a significant reduction in renal perfusion, which is a critical concern for CKD patients
However, they can also lead to nutrient depletion and digestive discomfort, including nausea, constipation, and digestive irregularity
The next generation of oral GLP-1s, such as Orforglipron and high-dose oral semaglutide, are showing weight loss results in trials that are much closer to those of their injectable counterparts
For those with osteoporosis, bone density is already low