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In short, this isnt something most primary care doctors are equipped to manage on the fly

Although data are sparse, the narrow therapeutic window (0.6 to 1.2 mEq/L) and the renal-clearance dependence of lithium make it worth monitoring serum levels after GLP-1 initiation, especially because GLP-1-driven nausea can reduce fluid intake and concentrate lithium

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Care should be taken when combining Tirzepatide with other blood sugar-lowering medications, as this could result in hypoglycaemia