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3) The use of a GLP-1 RA should be considered prior to initiation of insulin

[DOI] [PubMed] [Google Scholar] 28.Handelman G.J., Machlin L.J., Fitch K., Weiter J.J., Dratz E.A

All participants were on metformin at the maximum tolerated dose according to clinical and laboratory parameters (mean dose = 1500 mg), and none were taking other antihyperglycemic drugs including insulin analogues

Its low molecular weight enables distribution throughout the bloodstream, reaching multiple tissues simultaneously

Contact your healthcare provider if you're unable to keep fluids down or notice decreased urination

We thank the support of the National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) animal facility staff