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The Neurovascular Link: From a mechanistic standpoint, this reinforces the "vascular hypothesis" of neurodegeneration

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Ioannidou: [00:02:24] That's why you have to be very careful what you put out there

Limitations of Current Evidence Several significant limitations in the current evidence base warrant acknowledgment: Population Diversity : Most major trials have been conducted in predominantly white, well-resourced populations, potentially limiting generalizability to more diverse demographic groups where obesity prevalence is often highest

Men often carry weight differently than women, with more visceral fat around the abdomen, which can be more difficult to lose through diet and exercise alone