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Weight regain or glycemic deterioration after initial success suggests either adherence issues or progression of underlying disease

This softens the drug's early concentration peak, which is when nausea typically hits

Our guide on tirzepatide and headaches covers both prevention and treatment strategies

It is caused by reduced saliva production from GLP-1 receptor effects on salivary glands and from reduced chewing stimulation

Signs That Your Maintenance Dose May Need Adjustment Persistent GI symptoms that reduce daily function, a flatlining weight or glucose trend despite adherence, new medical conditions or medication changes, or sudden lifestyle alterations such as significant calorie increases or decreased activity are signals to revisit the dose

Dunham experienced a range of side-effects including nausea, migraines, and constipation, she said