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When the permeability of the mitochondrial membrane increases, ROS that are produced by the METC in mitochondria can be released into the cytosol and induce inflammation via signal transduction or toxic destruction of biological macromolecules [17]

Due to swallowing problems, the patient used a liquid KD formulation containing amino acids and medium- and long-chain triglycerides for 3 months

PMID: 67 ShaikhNWaterhlterAGnirckACBeckerMAdamiakVHennekenLet al

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In type 2 diabetes, glutathione depletion exacerbates hyperglycemia-induced ROS production, creating a feed-forward loop in which oxidative stress both results from and worsens insulin resistance (9)