semaglutide and gut health constipation explained Effects of semaglutide on metabolism

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Semaglutide primarily targets the GLP-1 receptor, while tirzepatide activates both GLP-1 and GIP receptors

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Patients prescribed a GLP-1 agent should also be encouraged to eat slowly, eat smaller meals, and if needed, adjust the timing of their GLP-1 dose in relation to food intake

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The retained water can put pressure on neurovascular structures, leading to numbness and tingling in the extremities, and in some cases, symptoms resembling carpal tunnel syndrome