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Aging (Albany NY) 2016;8, 2915-2926, doi:10.18632/aging.101100

Mesotherapy or intradermotherapy is a minimally invasive, nonsurgical procedure that consists of multiple intradermal injections of small quantities of various substances in solution, applied directly to the area to be treated.1 The technique was first described in 1958 by Pistor for the treatment of joint and muscle pain

in compound nevi, the lesional cells exist in the junctional and underlying connective tissue area

PMID 23945587

When using any transdermal medication, patients should avoid applying a new patch to the same exact location for at least one to two weeks, or as specified in the product labeling