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GLP-1 receptor agonists have demonstrated significant weight loss results in clinical trials, with participants losing 15% to 22% of body weight over 68 weeks
Accessed 8 Aug 2023 Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA
Furthermore, the interplay between ferroptosis and other fibrogenic pathways (e.g., TGF-/Smad and Wnt/-catenin) is fragmented
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These early effects help confirm the compound is active but don't represent full results
Once the microglia engulf the senescent neurons, they become senescent, dysfunctional and amplify pathogenesis through inflammation, releasing toxic tau and failure to survey the brain microenvironment
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