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Obesity-associated inflammation accelerates NAD consumption through activation of NAD-utilizing enzymes such as poly(ADP-ribose) polymerase 1 (PARP-1) and cluster of differentiation 38 (CD38) [85]

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RGC was reported in 17 (19%) of the GLP-1RA users as compared to 5 (5%) of the non-users, with an associated adjusted odds ratio (OR) increased by almost 6-fold (5.8 with 95% confidence interval [95% CI]: 1.719.3, P = 0.004)

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