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Mechanism of interaction between autophagy and apoptosis in cancer

Despite roughly five decades of work, no DSIP-specific binding site has been cloned, no DSIP gene has been isolated, and no signal-transduction pathway downstream of DSIP binding has been definitively characterized

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Studies in rodent models have shown that insulin resistance may lead to decreased expression of surface dopamine transporters in the striatum [55], decreased dopamine turnover [56], and decreased insulin-dependent dopamine release in the striatum [57]

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