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The fate of 1 -pyrroline-5-carboxylate (and its open-chain tautomer, glutamate -semialdehyde) depends on prevailing cellular conditions

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these metabolic changes are associated with a 50% reduction in cardiac adenosine triphosphate (ATP) levels and impaired cardiac function 6

The authors acknowledge funding support for this publication from Grant Number 13/RC/2073_P2, the Research Ireland CURAM Centre for Medical Devices, which is co-funded by the European Regional Development Fund

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Vitamin C is frequently used together with glutathione because it helps regenerate antioxidants and supports collagen synthesis, contributing to brighter and healthier looking skin