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Lai ZZ, Wang Y, Zhou WJ, et al

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It is noteworthy that besides DMF, several pharmacological strategies, including cysteine-independent direct inhibition of the Nrf2Keap1 complex formation, have been identified to activate the Nrf2 signaling pathway [50], which opens the way to the design of new effective drugs targeting this mechanism

Genome-wide association studies (GWAS) have decisively shown that more than half of AMD risk is genetically determined by two major genetic loci, one on chromosome 1 encoding for complement factor H and the other related complement genes and another one on chromosome 10 encoding for the HTRA 1 and ARMS 2 genes, along with a large number of minor gene loci that can modestly enhance protection against or risk of development of AMD [76]

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Use 23 times weekly at night