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Researchers rely on this documentation because impurities or degradation products can introduce confounding variables into a study, making results difficult to attribute to the compound being tested

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However, it has been shown that GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing UPR and promoting macroautophagy (69), and that postoperative increases in circulating cholic acid concentration contribute to improvements in glucose homeostasis after IT surgery by ameliorating ER stress (144)