Ryan SK, Zelic M, Han Y, Teeple E, Chen L, Sadeghi M, Shankara S, Guo L et al (2023) Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
DNA Repair & Epigenetic Modulation Proctor, P
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Impaired mitophagy in AD contributes to the accumulation of dysfunctional mitochondria and exacerbates A and hyperphosphorylated tau pathology
On the other hand, infiltrating CD8 + T cells also displayed significantly much higher levels of lipid ROS than splenic counterparts (Figure 1, D and E), suggesting that the balance between GSH and lipid ROS may contribute to their function
High-dimensional approaches (multiplex cytokine panels, mass cytometry, and single-cell RNA sequencing) consistently reveal PD-associated peripheral immune signatures elevated IL-6, TNF-, IL-1, shifts toward Th1/Th17 polarization, and expansion of pro-inflammatory monocyte subsets which correlate with motor severity and progression in multiple cohorts
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