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Tirzepatide receptor pharmacology and predicted receptor occupancy GIPR-forward dual-incretin design, cAMP-biased GLP-1R with low beta-arrestin, GCGR negative control (EC50 329 nM)

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BPC 157 markedly decreased the eNOS/Cav-1 binding and decreased Cav-1 binding, released the eNOS, and subsequently enhanced the activation of eNOS [121]