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For genetic perturbations that confer fitness defects, a negative -score defines synthetic sick and a positive -score defines buffering, respectively (Supplementary Data 3)

In the preliminary study, subjects remained on stabilised L-DOPA regimes, however in the phase 2 multicentre trial, subjects were not treated with L-DOPA

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When our body chemistry becomes unbalanced, it can wreak havoc on one or more of the complex systems our bodies use to function