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MC4R is predominantly expressed in the hypothalamus and plays a role in energy homeostasis and appetitive behavior pathways studied in animal models

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So what we have in the colon may actually be a kind of defence system regulating the mucosal integrity of the body

The total lifetime cost of bariatric surgery is frequently lower than years of GLP-1 medication, and the weight reduction is typically larger and more durable

Whereas much of the current attention surrounding GLP-1 RAs, or glucagon-like peptide-1 receptor agonists, has been focused on their unexpected and potent effect on weight loss, one important aspect of this class of drugs should not be overlooked: GLP-1 RAs have been shown to reduce the risk of heart attack, stroke, and other major adverse cardiovascular events (MACE) in patients with type 2 diabetes who have or are at high risk for atherosclerosis

Tirzepatide (Wegovy and Zepbound) is a dual agonist at the GLP-1 and GIP receptors and is administered once weekly