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The upper dermis (layer of the skin below the epidermis) may have some microscopic inflammation called mild superficial perivascular lymphocytic inflammatory changes

N Engl J Med 377(21):20632072 Liu L et al (2022) Clostridium butyricum potentially improves immunity and nutrition through alteration of the microbiota and metabolism of elderly people with malnutrition in long-term care

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doi: 10.1021/acscentsci.9b01063 50 SoulaMWeberRAZilkaOAlwaseemHLaKYenFet al

I'm getting different answers for things, but in general, it looks like it can be anywhere from like 14 hours on the low end to up to 72 hours on the high end, like three days

[23] In addition, it has also been shown to directly scavenge ROS, block lipid peroxidation and maintain mitochondrial integrity under hypoxia and trauma