glp-1 and osteoporosis New Research on GLP-1s & Bone Health 🦴 ​A new large-scale study has raised questions about the long-term effects of receptor agonists (like Ozempic Wegovy). While these medications are revolutionary The effects of GIP, GLP-1

Semaglutide (Ozempic, Wegovy) has a half-life of approximately 7 days and takes about 5 weeks (five half-lives) for 97% clearance from the body after the final injection

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

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However, dedicated studies are needed to test the translatability of the preclinical data of amylin and calcitonin dual agonism and to delineate the separate and combined physiological effects of amylin and/or calcitonin receptor activity in humans

However, combining these medications should be done under strict medical supervision to avoid potential risks such as hypoglycemia, where blood sugar levels drop too low

Anthony MS et al