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This sleep disruption caused by caffeine sets the stage for elevated ghrelin and suppressed leptin upon waking, thereby indirectly undermining the weight management benefits promoted by semaglutide, which relies heavily on appetite regulation via these hormonal pathways

It regulates blood sugar by stimulating insulin release in response to food, suppresses appetite by signaling satiety, slows gastric emptying to reduce glucose spikes, and reduces cravings making it a critical component of healthy metabolic balance

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Metformin can also cause gastrointestinal side effects such as diarrhea, nausea, and abdominal discomfort