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While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3

DOI Maquart FX, Pickart L, Laurent M, et al

FSH, follicle-stimulating hormone

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The hypothalamus (via releasing hormones) tells the pituitary - the primary hormone signaling gland in the brain - what to do