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The substantial increase in plasma bile acid concentrations (primary, secondary, total and unconjugated bile acid concentrations) with metformin may be explained by the fact that metformin increased the abundance of probiotic bacteria, especially Lactobacillus , and thus their bile salt hydrolase (BSH) gene expression

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Some may experience minor side effects like bruising at the injection site, but these are typically short-lived

How tirzepatide works differently than semaglutide This is where things get interesting